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Someamphiphilic polymers manifest responsive properties in water that vary as a function of their chemical composition,molar mass and concentration.The addition of salt and surfactants to the solution can also modify the thermoresponsiveness of such polymers,but the effect of host-guest complexationon the thermoresponsiveness of the polymers remains less explored.We have designed and synthesized copolymers of N-alkyl acrylamides withcomonomersbearing cholic acid pendant groupsand studied the effect of host-guest complexation between the bile acid pendant and cyclodextrin.