【摘 要】
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Objective Lipoxins represent a unique class of lipid mediators that can function as "braking signals" in inflammation.Lipoxin A4 (LXA4) and LXB4 are positional isomers.In addition, a synthetic analogu
【机 构】
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Department of Integrative Medicine and Neurobiology, Shanghai Medical College, Institute of Acupunct
【出 处】
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中国神经科学学会第九届全国学术会议暨第五届会员代表大会
论文部分内容阅读
Objective Lipoxins represent a unique class of lipid mediators that can function as "braking signals" in inflammation.Lipoxin A4 (LXA4) and LXB4 are positional isomers.In addition, a synthetic analogue of ATL (aspirin-triggered lipoxin) has the same anti-inflammatory activities as the endogenous lipoxins and is more resistant to metabolic inactivation.It has been reported that both Lipoxins and aspirin-triggered lipoxins can inhibit inflammation pain.In bone cancer pain, many researches have indicated that the neuroinflammation involved in the pain processing.In this article, we performed a series of studies on the role of ATL in bone cancer pain.Methods Female SD rats (160-180 g) were used to establish the model of bone cancer pain by percutaneous direct puncture technique and inoculating the Walker256 mammary gland carcinoma cells into right tibial medullary cavity directly.The mechanic allodynia of rats were evaluated by von Frey hair and we gave the drugs by intrathecal administration.Results (1) Compared to the vehicle-treated animals, intrathecal LXA4, LXB4 and ATL can up-regulate mechanical threshold; (2) ATL has a longer anti-allodynic effect than the other lipoxin analogues.Conclusion Both Lipoxins and the analogy of lipoxins have anti-allodynic effects in tibial bone cancer pain.However, the molecular mechanism of lipoxins in bone cancer pain is still unclear and need to be further studied.
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