Analyzing the optokinetic responses for detecting the effects of anxiolytic drugs on zebrafish larva

来源 :中国神经科学学会第九届全国学术会议暨第五届会员代表大会 | 被引量 : 0次 | 上传用户：liongliong440

【摘要】

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【作者】

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Si-Jie CHEN Gang PENG

【机构】

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Institutes of Brain Science, Fudan University, Shanghai 200032, China

【出处】

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

【发表日期】

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2011年1期

【关键词】

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OKR anxiolytic drugs visual system

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　　Optokinetic response (OKR) is a reflexive response which is elicited by a slowly moving image across the retina.The stimulation is generated by a drum with black-white vertical stripes on its internal wall horizontally rotating around the larvae.We treat 8-9 dpf larvae by either egg water or drugs for an hour before the experiments.The larvae are then transferred to a 3.5 cm-diameter petri dish containing 6% methylcellulose at the center of the drum.Images of the optokinetic responses are captured by CCD camera and processed by Image-J to analyze the effects of anxiolytic drugs on visual system.

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Analyzing the optokinetic responses for detecting the effects of anxiolytic drugs on zebrafish larva

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