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Introduction: To understand the expression levels of Tim-3, a new proinflammatory factor in the early stages of Echinococcus granulosus infection in mice.Through the establishment of animal models of Echinococcus granulosus (E.granulosus) infected mice, we explored whether E.granulosus promote Tim-3 up regulation on the macrophage, and then inhibits its activity.Methods: Balb/c mice were infected with E.granulosus.Peritoneal macrophages and spleen cells were colle.