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The importance of maternal nutrition for fetal brain development is increasingly recognized.Previous studies have suggested that maternal obesity or maternal exposure to obesogenic diets may permanently alter brain structure and function in the offspring.To test whether maternal exposure to a high-fat diet, prior and during gestation, alters fetal hippocampal development, we fed 8-week old C57BL/6 females with a high-fat diet (60% calories from fat) for 10 weeks prior to matting and 17 days after.Fetal brains at embryonic day E17 were used to determine developmental changes in the hippocampus.