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Canonical Wingless (Wg)/Wnt signaling plays an evolutionarily conserved role in dictating cell proliferation,pattern formation,stem cell maintenance and adult tissue homeostasis.Although core components of the Wg/Wnt signaling cascade have been identified,gaps in the understanding of this critical signaling pathway still remain to be filled.To unveil novel regulators of Wg signaling,we conducted a genome-wide RNAi screen in the developing Drosophila wing,from which a RNA binding exon junction complex (EJC) emerged as a positive regulator of Wg signaling.