【摘 要】
:
In adult cortical circuits, the ratio of excitatory and inhibitory conductances is presumably balanced across a wide range of stimulus conditions.However, it is unknown how the E/I ratio is postnatall
【机 构】
:
University of Wyoming USA
论文部分内容阅读
In adult cortical circuits, the ratio of excitatory and inhibitory conductances is presumably balanced across a wide range of stimulus conditions.However, it is unknown how the E/I ratio is postnatally regulated, when the strength of synapses are rapidly changing.Yet, understanding of such a process is critically important, because there are numerous neuropsychological disorders, such as autism,epilepsy and schizophrenia, are associated with disturbed E/I balances.
其他文献
NMDA receptor (NMDA-R) antagonists elicit psychotic symptoms in human and schizophreniarelevant signs in rodents, including a strong increase in gamma activity in different cortical areas.NMDA-Rs are
Saab B J, Mun H-S, Georgiou J, Nath A, McGirr A, Mansuy IM, Roder JC.Brain Research Institute, University of Zürich Swiss Federal Institute of Technology, Zürich, Switzerland; Samuel Lunenfeld Researc
Alzheimers disease (AD) is a multifactorial complex disease.The failure of recent development of AD therapeutic agents in clinical trials is partly due to their single-target effect.We have studied tr
The current prevailing theory of NMDA receptor (NMDAR)-mediated cell death postulates that synaptic and extrasynaptic NMDAR have counteracting effects: activation of synaptic receptors leads to surviv
Cortical spreading depression (CSD) is a transient disruption of ionic homeostasis, followed by depression that can propagate slowly across the cortex.This phenomenon is believed to promote changes in
Glutamate neurotransmission is widely represented in brain and in retina in particular, which is regarded as a biological model of central nervous system.The glutamate NMDA (N-methyl-Daspartate) recep
Both the delta-opioid receptor (DOR) and brain-derived neurotrophic factor (BDNF) are neuroprotective against hypoxic/ischemic injury.However, the mechanisms underlying their actions are not clearly u
There are many hypotheses suggesting metabolic pathways regulating sleep/wake switch, and the major function of astrocytes has been known as supplying metabolic resources and removing metabolites for
Among the many systemic implications caused by Chronic Obstructive Pulmonary Disease (COPD), impaired muscle function is particularly deleterious because it involves both the level of activity and qua
Since the discovery of the NMDA receptor GluN3A or NR3A subunit, the functional role of this unique inhibitory subunit has been largely obscure.GIuN3A expression is high in the neonatal brain but decl