Actin-bundling protein Fascin1 is required for early endosome trafficking of TGF-β type I receptors

来源 :第三届“模式生物与人类健康”发育遗传学全国学术研讨会 | 被引量 : 0次 | 上传用户：peterqiu123

【摘要】

：

Actin cytoskeleton plays an essential role in multiple stages of clathrin-mediated endocytosis including endocytic vesicle formations,pinching off the plasma me

【作者】

：

LIU Zhao-Ting XU Ran-Ran CAO Yu WANG Qiang

【机构】

：

StateKeyLaboratoryofBiomembraneandMembraneBiotechnology,InstituteofZoology,ChineseAcademyofSciences,

【出处】

：

第三届“模式生物与人类健康”发育遗传学全国学术研讨会

【发表日期】

：

2014年7期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

Actin cytoskeleton plays an essential role in multiple stages of clathrin-mediated endocytosis including endocytic vesicle formations,pinching off the plasma membrane,trafficking and selective fusion with endosomal/lysosomal compartments.Clathrin-mediated endocytosis is important in regulating signal transduction and mediating the formation of specialized signalling complexes.

其他文献

AtRBOHF-ROS介导了Na+吸收调控和高盐胁迫应答

高盐胁迫是影响农业生产的主要非生物胁迫之一,因此研究植物抗盐胁迫应答的分子机制具有重要的科学理论意义和潜在的应用价值.近年来通过反向遗传学技术鉴定出了许多重要的抗

会议

植物高盐胁迫钠离子吸收调控蛋白表达

DNA demethylation confers competence on the genome for zygotic genome activation in zebrafish embryo

The zygotic genome of animal embryos is transcriptionally inactive upon fertilization,and becomes active after a certain period of development.As transcription

会议

Conditional Knockouts Generated by Engineered Endonuclease Reveal Roles of Coronin in C.elegans Neur

Animals with conditional gene knockouts are valuable tools for studying mechanisms underlying cell and developmental biology.We have developed a conditional kno

会议

progenitors via suppression of ERK activation

In mouse mid-gestational embryos,definitive hematopoietic stem progenitor cells are derived directly from a very small proportion of the arterial endothelium.Ho

会议

Synergistic function of Kras mutation and HBx in initiation and progression of hepatocellular carcin

Although the activation of Ras pathway is frequently observed in human hepatocellular carcinoma (HCC),the in vivo role of Ras activation in HCC initiation and p

会议

斑马鱼fhlA在骨骼肌发育中的作用

调控骨骼肌发育的分子机制尚不完全明了.有证据显示LIM-only蛋白FHL1与骨骼肌的生长以及人体骨骼肌病有关联,但FHL1在骨骼肌发育中的作用还有待阐明.本文以斑马鱼为模型研究

会议

骨骼肌发育fhlA基因RA信号通路卫星细胞

Blocking Follistatin-like 1 attenuates pulmonary fibrosis in mice

Progressive tissue fibrosis is a cause of major morbidity and mortality.Pulmonary fibrosis is an epithelial-mesenchymal disorder in which TGF-β1 indubitably pl

会议

PDGFα受体维持胃癌循环肿瘤干细胞存活的机制

Gastric cancer is the fourth most common cancer worldwide,with a high rate of death and low5-year survival rate.To date,there is a lack of efficient therapeutic

会议

胃癌病理机制PDGFα受体肿瘤干细胞

RESP18基因敲除小鼠构建及行为表型分析

可调节内分泌特异性蛋白18(RESP18)基因特异性表达于哺乳动物中枢神经系统和内分泌系统,是一种功能未知的分泌肽基因.本文利用基因重组技术,成功构建了RESP18基因条件敲除小

会议

哺乳动物RESP18基因行为学表型分析听震惊反射强度

KLF5调控上皮细胞极性影响肺管腔发育的机制

肺依赖于其高度分支的管腔系统实现与外界的气体和物质交换.前期研究显示转录因子KLF5的组织特异性的敲除会分别导致肺,肠、肾脏等多个器官的发育障碍.尽管KLF5调控组织特异

会议

肺管腔发育上皮细胞极性分子机制KLF5基因

Actin-bundling protein Fascin1 is required for early endosome trafficking of TGF-β type I receptors

其他学术论文