SMAD7 overexpression in T cells leads to spontaneous intestinal inflammation in CYLD mutant mice

• 作 者: YilangTang;SonjaReissig;AriWaisman;
• 机 构: University Medical Centre of the University of Mainz,Institute for Molecular Medicine
• 出 处: 中国免疫学会第十届全国免疫学学术大会
• 发表日期: 2015年期

　　CYLD plays an important role in different signaling pathways such as NF-κB, JNK and TGF-β signaling.Hvelmeyer et al.generated CYLDex7/8 mice, which express excessively a naturally occurring splice form of CYLD (sCYLD), while the full length protein (FL-CYLD) is missing.Data illustrated the important role of sCYLD in B cells, T cells and DCs using the CYLDex7/8 mouse model.