【摘 要】
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Objective Ginseng,has been used in China and other countries over 2 000 years,has multi-modulations on Central Nervous System,(CNS) as "adaptogen".It was sh
【机 构】
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Laboratory of Molecular Neurobiology, College of Life Science and Technology, University of Electron
【出 处】
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中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
Objective Ginseng,has been used in China and other countries over 2 000 years,has multi-modulations on Central Nervous System,(CNS) as "adaptogen".It was showed Ginsenoside Rb 1 (Gs-Rb 1,25-hydroxy-ginsenoside-Rhl,40 mg/kg),one of main components isolated from ginseng,significantly decreased the free-movement-times of mice in our previous experiment.It intended in this experiment to investigate the effect of Gs-Rbl (ip) on electrocorticography (EcoG),learning and memory of rats,and to analyze the effective pattern of Gs-Rbl on the sleep process and the initial stage of awaking of rats.Methods (1) EcoG of sleep recording:Sixteen male rats (250-300 g) were randomly divided into 2 groups:Control for EcoG (CE) and Gs-Rb1 treated for EcoG group (GTE),8 rats in each group.Each rat was set the stainless steel screws on the cerebral cortex through the skull (Coordinate of Record point:A/P-0.8,M/L +3.0; Coordinate of reference point:A/P +2.7,M/L-3.0).The baseline EcoG including sleep-status and waking-status was recorded a week after the operation.GTE group rats were administrated (i.p.) Gs-Rbl at 40 mg/kg per day for 3 d from day 7 to day 9 after the electrodes were embedded.CE group rats were accordingly administrated (i.p.) with equal volume of normal solution (NS).
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