Glucagon-like peptide 1 stimulates insulin secretion via inhibiting RhoAROCK signaling and disassemb

来源 :中国生理学会第24届全国会员代表大会暨生理学学术大会 | 被引量 : 0次 | 上传用户：KurtJohns

【摘要】

：

　　Aims/hypothesis chronic hyperglycemia results in impaired glucose-stimulated insulin secretion (GSIS).Glucagon-Like Peptide-1 (GLP-1) reverses glucotoxicity

【作者】

：

马晓松严丹孔祥臣 Jiangming Sun 吴学蕊 Hindrik Mulder Xianxin Hua

【机构】

：

深圳大学糖尿病研究所,深圳518060LundUniversityDiabetesCentre,UnitofMolecularMetabolism,SE-20502,Malm(o),SwedenUni

【出处】

：

中国生理学会第24届全国会员代表大会暨生理学学术大会

【发表日期】

：

2014年10期

【关键词】

：

GLP-1 glucotoxicity actin cytoskeleton PKA RhoA/ROCK

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　　Aims/hypothesis chronic hyperglycemia results in impaired glucose-stimulated insulin secretion (GSIS).Glucagon-Like Peptide-1 (GLP-1) reverses glucotoxicity-perturbed GSIS.We explored whether organization and remodeling of the actin cytoskeleton is implicated in glucotoxicity,and potentially in the protective effects of GLP-1 on GSIS.

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Glucagon-like peptide 1 stimulates insulin secretion via inhibiting RhoAROCK signaling and disassemb

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