Complement-mediated macrophage polarization in perivascular adipose tissue contributes to vascular i

来源 :中国生理学会第24届全国会员代表大会暨生理学学术大会 | 被引量 : 0次 | 上传用户：xiaoxiaofan0303

【摘要】

：

Objective:We have previously shown an increased expression of complement 3 (C3) in perivascular adipose tissue (PVAT) in the deoxycorticosterone acetate (DOCA)-

【作者】

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Cheng-Chao Ruan Dong-Rui Chen Yan Li Xiao-Dong Li Ping-Jin Gao

【机构】

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StateKeyLaboratoryofMedicalGenomics,ShanghaiKeyLaboratoryofHypertension,DepartmentofHypertension,Rui

【出处】

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中国生理学会第24届全国会员代表大会暨生理学学术大会

【发表日期】

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2014年10期

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Objective:We have previously shown an increased expression of complement 3 (C3) in perivascular adipose tissue (PVAT) in the deoxycorticosterone acetate (DOCA)-salt hypertensive model.This study aims to determine the role and underlying mechanism of C3 in PVAT and the pathogenesis of hypertensive vascular remodeling.Approach and Results:We found that C3 is primarily expressed in macrophages in PVAT of blood vessels from DOCA-salt mice.We then investigated the role of C3 in macrophage polarization using peritoneal macrophages from wild-type (WT) and C3-deficient (C3KO) mice.

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Complement-mediated macrophage polarization in perivascular adipose tissue contributes to vascular i

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