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Heparan sulfate proteoglycans of the glypican family regulate Wnt signalling and convergent extension in vertebrate embryos.They are predicted to be glycosylphosphatidylinositol (GPl)-tethered membrane bound proteins, but there is no functional evidence of their regulation by the GPI synthesis complex.Down syndrome critical region protein 5 (Dscr5) is a component of GPI-N-acetylglucosaminyltransferase (GPI-GnT) complex, and is associated with specific features of Down syndrome.We show that Dscr5 regulates cell movements during vertebrate gastrulation through the non-canonical Wnt pathway.Both overexpression and knockdown of Dscr5 impair cell movements without significant effect on mesoderm patterning.