Effective Forms, Additive Effect, and Toxicities Scattering Effect of Pharmacodynamic Substances of

• 作 者: Shao-Qing Cai Feng Xu Dong-Hui Yang Ming-Ying Shang Xuan Wang
• 机 构: School of Pharmaceutical Sciences, Peking University
• 出 处: 第十四届全国中药和天然药物学术研讨会暨第十三届中药全球化联盟大会
• 发表日期: 2014年8期
• 关键词: pharmacodynamic substances Effective Forms Additive Effect metabolit Toxicities

The blood concentrations of the pharmacodynamic substances of traditional Chinese medicines (TCMs) are usually very low.How can they exert pharmacological actions? In which forms (original form, metabolite or the both) do they exert the actions? To answer these questions, we proposed a new concept of "Effective Forms" of pharmacodynamic substances of TCMs and a hypothesis of additive effect of multiple constituents of TCMs.