【摘 要】
：
目的 胚胎期急性严重缺氧可导致新生儿神经发育异常,伴随可持续至成年的运动、认知和/或精神障碍.高海拔(＞3500m)低压低氧环境适应对胚胎期缺氧有一定的保护效应,而在中海拔(1500-2000m)低压低氧环境的适应是否也会对胚胎期缺氧有一定的保护效应目前尚不明确.昆明海拔约1900m,氧分压为平原地区的80％,属中海拔地区.
【机 构】
：
云南白药集团创新药物研发中心;云南省药物研究所药物安全性评价研究中心;云南省中药和民族药新药创制企业重点实验室,昆明650111
【出 处】
：
2015年(第五届)药物毒理学年会
论文部分内容阅读
目的 胚胎期急性严重缺氧可导致新生儿神经发育异常,伴随可持续至成年的运动、认知和/或精神障碍.高海拔(＞3500m)低压低氧环境适应对胚胎期缺氧有一定的保护效应,而在中海拔(1500-2000m)低压低氧环境的适应是否也会对胚胎期缺氧有一定的保护效应目前尚不明确.昆明海拔约1900m,氧分压为平原地区的80％,属中海拔地区.
其他文献
Background,Motivation and Objective Burst-mode focused ultrasound(FUS) exposure with the presence of microbubbles has shown its promise in temporally and targeted open the blood-brain barrier(BBB),and
Background,Motivation and Objective Histotripsy is a non-invasive,controllable and fine focused ultrasound surgery method using microsecond or millisecond pulse with peak negative pressure larger than
Background,Motivation and Objective Acoustic cavitation bubbles can accelerate therapeutic effect in high-intensity focused ultrasound(HIFU) treatments.In our previous study,it was demonstrated that s
Background, Motivation and Objective The fundamental ultrasonic guided modes (UGM) are consistently observed in long bones in vitro and in vivo. The responses of UGM to the changes of cortical thickne
Background,Motivation and Objective Quantitative ultrasonic characterization of cortical bone based on the analysis of the waveguide response of the cortical shell of long bones has been reported.Howe
Background,Motivation and Objective BUA(Broadband Ultrasonic Attenuation) is an accepted indicator of trabecular bone status.To examine the bones lying deep in the human body one can use scattered wav
Background,Motivation and Objective Ultrasound bidirectional axial transmission(BDAT) has been originally developed to measure the speed of sound of the first arriving signal(VFAS) in the cortex of lo
Background,Motivation and Objective Measurements of guided modes dispersion relations,along with suitable waveguide modeling,have the potential for inferring material and structural properties of cort
目的:吡咯喹啉醌(pyrroloquinoline quinone,PQQ)是一种由多种革兰阴性菌产生的,继烟酰胺、核苷酸和黄素核苷酸后发现的第三类氧化还原酶的辅酶,具有抗氧化、清除自由基、抑制肿瘤生长等多种生理功能,PQQ在疾病预防与治疗方面也有显著作用,近年来受到广泛关注.
为了预测化合物T对生殖机能及子代发育可能产生的不良影响,进行了2代生殖发育毒性试验.试验过程中观察到部分雌鼠有难产现象,因此进行了若干研究性生殖毒性试验及作用机理探索试验,对化合物T诱导大鼠难产现象的原因进行深入研究并对人体分娩是否有潜在风险进行了分析讨论.