论文部分内容阅读
Background: Human xenografi tumor models are widely used for evaluation of potential cancer targets, by assessing the anti-tumor effects of specific agents, such as siRNA, siRNA is usually stably introduced into tumor cells prior to transplantation.However, oncogene silencing results in reduced cell growth/survival in vitro and/or failure to establish tumors in vivo, thus hindering tumor response-based efficacy evaluation that is more clinically relevant.We therefore explored a new tumor response model based on regulated RNAi.