【摘 要】
：
Virostatics are drugs combining antiviral and cytostatic properties.The ctytostatic (prevention of cell proliferation) activity of Virostatics represents a
【机 构】
：
Scientific Director, RIGHT-Research Institute for Genetic and Human Therapy, Italy
【出 处】
：
2005 WHTS'3rd Annual Congress of International Drug Disc
论文部分内容阅读
Virostatics are drugs combining antiviral and cytostatic properties.The ctytostatic (prevention of cell proliferation) activity of Virostatics represents a novel mechanism of action, in addition to the known antiviral activity of some Virostatic combinations, such as mycophenolate and abacavir, or hydroxyurea and didanosine.Preventing cell proliferation breaks the pathogenic circle cell proliferation-HIV replication-cell proliferation.In fact, persistent HIV replication induces chronic immune stimulation, resulting in T cell activation and proliferation, and consequently, in the exhaustion of the immune system.In tum, cell proliferation sustains HIV replication, because proliferating cells produce a higher number of viral particles.At present, no antiretroviral drug addresses the issue of over-proliferation of immune competent cells.
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