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We investigate a microbubble generation of the defected-decorated microfiber via optical trapping yeast cells and burning them with the photothermal ef-fect.The diameter of the microfiber is ~ 6 m.The yeast cells which suspended in water are trapped at the defect of the microfiber when an 1550 nm laserbeam at 20 mW power is injected into the microfiber.