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AIM: To observe the presence and expression of Indoleamine 2,3-dioxygenase(IDO)during the corneal immunity to Aspergillus fumigatus(A.fumigatus)inof the murine models.METHODS:The murine model of fungal keratitis was established by smearing with colonies of A.fumigatus after scraping central epithelium of cornea and covering with contact lenses in C57BL/6 mice,and the mice were randomly divided into the control group,sham group and A.fumigatus keratitis group.