【摘 要】
：
Wnt signaling plays important roles in various physiological and pathophysiological processes.The pathway that leads to β-catenin stabilization is initiate
【机 构】
：
StateKeyLaboratoryofMolecularBiology,InstituteofBiochemistryandCellBiology,ShanghaiInstitutesforBiol
【出 处】
：
Wnt信号、器官发育和干细胞国际学术大会(Wnt Signaling,Organogenesis,and Stem Ce
论文部分内容阅读
Wnt signaling plays important roles in various physiological and pathophysiological processes.The pathway that leads to β-catenin stabilization is initiated by Wnt binding to its cell surface receptors, which induces the formation of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2]via activation of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) type I.Here, we show that Wnt also stimulated the production of phosphatidylinositol 4-phosphate [PtdIns(4)P], which depended on Frizzled (Fz), Disheveled (Dvl) and phosphatidylinositol 4-kinase (PI4K) type IIα.
其他文献
Tcf is a transcription factor influencing the transcription of several genes thereby exerting a large variety of functions in the cell.Tcf is known for down
Nuclear hormone receptors (NHRs) are transcription factors which are important for many physiological functions, such as development, cellular differentiati
Oligodendrocytes are the myelinating cells in the central nervous system.The development of oligodendrocytes is mediated by complex signaling networks, incl
Lrp5/6 are crucial co-receptors for Wnt/beta-catenin signaling, a pathway biochemically distinct from non-canonical Wnt signaling pathways.Here we examined
Wingless(Wnt) is involved in embryonic and adult progenitor cells differentiation, and has the ability to promote or inhibit cardiogenesis.However, the role
Heparan sulfate proteoglycans of the glypican family regulate Wnt signalling and convergent extension in vertebrate embryos.They are predicted to be glycosy
The human and mouse genomes sequencing and annotation have provided a great wealth of accurate information on gene structure and variability, which can be e
Lef-1 is a terminal effector in the wnt signaling pathway.There are several Lef-1 isoforms derived from either pre-RNA splicing or alternative promoter usag
Wnt/β-catenin signaling pathway is essential for development and tumorigenesis.It plays a critical role in directing cell fates during embryogenesis of ani