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  5. -94 ATTG insertion/deletion polymorphism of the NFKB1 gene is associated with coronary artery diseas

-94 ATTG insertion/deletion polymorphism of the NFKB1 gene is associated with coronary artery diseas

来源 :第十二届中国介入心脏病学大会(CIT2014) | 被引量 : 0次 | 上传用户：gpi678c
【摘 要】
：
Background The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway plays a key role in the regulatory network of inflammation.The deletion variant allele of the NF
【作 者】
：
Yang Yining Abulizi Annivaer Zhang Jinyu Ma Yitong Xie Xiang 
【机 构】
：
Department of Cardiology,First Affiliated Hospital of Xinjiang Medical University,Xinjiang,China
【出 处】
：
第十二届中国介入心脏病学大会(CIT2014)
【发表日期】
：
2014年3期
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Background The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway plays a key role in the regulatory network of inflammation.The deletion variant allele of the NFKB 1-94 ins/del ATTG promoter polymorphism leads to lower transcription levels of the p50 subunit,and the variant allele has been associated with several inflammatory diseases as well as CAD with inflammation as an important part of the pathogenesis.The aim of the present study was to assess the association between the human NFKB1 gene polymorphism and CAD in a Han and Uygur population of China.
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