顺铂对肝癌细胞中miR-133b靶向PPP2R2D调控的影响

来源 :全国卫生毒理学术研讨会 | 被引量 : 0次 | 上传用户：Crownless

【摘要】

：

目的：顺铂(cDDP)作为细胞周期非特异性抗肿瘤药应用于一线抗肝癌(HCC)的高效化疗；有研究表明cDDP可导致HCC细胞周期阻滞而抑制增殖；而且人群中肝癌对cDDP治疗的敏感性不同。蛋白磷酸酶2A(PP2A)通过对信号通路分子的去磷酸化作用,参与调控细胞增殖、细胞周期、DNA损伤修复等过程；其中B55δ亚基由PPP2R2D基因编码,我们前期研究验证该基因3,UTR+ 15 G＞C多态性位点受mi

【作者】

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庄群瑛于诗若蒋盛威石嘉章覃舒琪何承勇林忠宁林育纯

【机构】

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厦门大学分子疫苗学和分子诊断学国家重点实验室,公共卫生学院

【出处】

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全国卫生毒理学术研讨会

【发表日期】

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2014年9期

【关键词】

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顺铂(cDDP) 原发性肝细胞癌(HCC) PP2A-B55δ 3'UTR多态性 miR-133b

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顺铂对肝癌细胞中miR-133b靶向PPP2R2D调控的影响

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