Hypercholesterolemia in Rats with Hepatomas:Increased Oxysterols Accelerate Efflux but does not Inhi

来源 :第五届生命之春论坛 | 被引量 : 0次 | 上传用户：alexhome

【摘要】

：

　　F INTRODUCTION:Hypercholesterolemia is one of the important paraneoplastic syndromes in patients with hepatoma(s), but the nature of the defect has not been

【作者】

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YasushiMatsuzaki;AkiraHonda;TakeshiHirayama;TeruoMiyazaki;TadashiIkegami;

【机构】

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Department of Gastroenterology Tokyo Medical University Kasumigaura Hospital

【出处】

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第五届生命之春论坛

【发表日期】

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2008年期

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　　F INTRODUCTION:Hypercholesterolemia is one of the important paraneoplastic syndromes in patients with hepatoma(s), but the nature of the defect has not been completely elucidated.We investigated the molecular mechanisms of hypercholesterolemia in a bepatoma-bearing rat model.METHODS:Buffalo rats were implanted in both flanks with Morris hepatoma 7777 (McA-RH7777) cells.After 4 weeks, the animals and untreated control rats were sacrificed and the tumors, liver and blood were collected from each rat.

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Hypercholesterolemia in Rats with Hepatomas:Increased Oxysterols Accelerate Efflux but does not Inhi

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