EFFECT OF ATORVASTATIN ON ENDOTHELIUM-DEPENDENT RELAXATION OF SMALL PULMONARY ARTERIES IN MONOCROTAL

来源 :第二十四届长城国际心脏病学会议、亚太心脏大会暨国际心血管病预防与康复会议(The 24th Great Wall Int | 被引量 : 0次 | 上传用户：renx2000

【摘要】

：

【作者】

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Jiang Zhi Liangdi Xie

【机构】

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First Hospital of Longyan Fujian Hypertension Res

【出处】

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第二十四届长城国际心脏病学会议、亚太心脏大会暨国际心血管病预防与康复会议(The 24th Great Wall Int

【发表日期】

：

2013年2期

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Objectives To examine the preventive effect of atorvastatin on acetylcholine (Ach)-induced endothelium-dependentrelaxation (EDdR) in small pulmonary artery (SPA) rings in monocrotaline (MCT)-inducedpulmonary hypertension rats.Methods 72 MaleSD rats were randomly assigned into four groups: normal control (Ctr), pulmonaryarterial hypertension (PAH), PAH preventively treated with 5 mg/kg/d (Lator)and 10 mg/kg/d (Hator) atorvastatin respectively.Rats were sacrifiedat the end of 1st, 2nd and 4th wks after administration.

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EFFECT OF ATORVASTATIN ON ENDOTHELIUM-DEPENDENT RELAXATION OF SMALL PULMONARY ARTERIES IN MONOCROTAL

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