【摘 要】
：
An electrochemical approach to the intramolecular aminooxygenation of unactivated alkenes has been developed.This process is based on the addition of nitrog
【机 构】
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The Key Laboratory of Chemical Biology of Fujian Province College of Chemistry and Chemical Engineer
【出 处】
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中国化学会全国第十二届有机合成化学学术研讨会
论文部分内容阅读
An electrochemical approach to the intramolecular aminooxygenation of unactivated alkenes has been developed.This process is based on the addition of nitrogen-centered radicals,generated through electrochemical oxidation,to alkenes followed by trapping of the cyclized radical intermediate with 2,2,6,6-tetramethylpiperidine-Noxyl radical(TEMPO).Difunctionalization of a variety of alkenes with easily available carbamates/amides and TEMPO affords aminooxygenation products in high yields and with excellent trans selectivity for cyclic systems(d.r.up to>20:1).The approach provides a much-needed complementary route to existing cis-selective methods.
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