Diallyl Trisulfide (DATS) suppresses breast cancer metastasis:an effect controlled by the thioredoxi

• 作 者: 刘玉萍[1]韦忠红[1]盛晓波[1]沈颖[1]曹玉珠[1]单云龙[1]王旭[1]沈培亮[1]王爱云[2]陈文星[2]陆茵[2]
• 机 构: 南京中医药大学药学院药理教研室
• 出 处: 2015医学前沿论坛暨第十四届全国肿瘤药理与化疗学术会议
• 发表日期: 2015年期

　　Introduction We have recently found Diallyl Trisulfide(DATS), a natural product of garlic,which has shown anti-cancer metastasis activity.We investigated its efficacy and mechanism of action in the treatment of triple-negtive breast cancer in preclinical models.Methods We evaluated the anti-breast-cancer migration and invasion efficacy of DATS in human triple-negative, i.e., estrogen receptor-negative, progesterone receptor-negative and HER2-negative (MDA-MB231、 HS 578T) breast cancer cell lines the most difficult-to-treat (triple-negative) subtypes of breast cancer-and their metastasis model in nude mice.