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Background: Breast cancer is the most frequently diagnostic cancer for the females in China according to the China cancer registry in 2011.However, there are not systemic retrospective data about the breast cancer status including the ethnic groups in China.Uygur and Hui ethnic are major in Xinjiang Uygur and Ningxia Hui Autonomous Region of China.Their incidence, pathologic and treatment status are not very clear.This is a first breast caner racial difference study about the Uygur ,Hui and Han groups in Western china.Methods: A retrospective study about 1664 cases who were diagnosed with breast cancer between April 2008 to October 2012 from Western china including Xinjiang Uygur and Ningxia Hui Autonomous Region.Descriptive statistics were employed to analyze the epidemiological and clinical data.Among them, there are 297 cases of Uygur and 119 cases of Hui.With the comparison of Uygur and Hui ethnic group, 1248 breast cancer cases of Han ethnic group from West of china ,which were enrolled randomly according to one to three ratios as the control group at the same time.Results: 1664 breast cancer patients were analyzed.The peaks of disease age with breast cancer in western china were from 42 to 47 years old generally.With the separate analysis, the peaks of disease age with breast cancer were shown at 34 years old and from 39 to 45 years old for Uygur ethnic group and from52 to 56 years old for Hui ethnic group.The age at diagnosis was significantly different among Han ,Uygur and Hui ethnic groups(P<0.001).Even though it was a trend that nearly 60% cases of breast cancer was in premenopausal status among three groups, the highest percentage of age in premenopausal state was in Uygur group about 70.7%.Concerning the times of pregnancy and birth, we found that it was significantly different in three groups (P<0.001).Even though it was no different in subtypes from one to three times of pregnancy and birth, more than three, times of birth and pregnancy had higher proportion in Uygur group about 23.2% and 43.4% separately, compared in Han group about 8.6% and 24.1%,and Hui groups about 14.3% and 28.6%.In aspect of tumor stage, it was significantly different for tumor size and lymph node status among three groups.The proportion for the more than 5cm of tumor size and the more than threepositive nodes was highest in Uygur group.It accounted for 8.8% and 48.8% separately in Uygur group, when tumor size was more than 5cm, and it was more than three positive lymph nodes.In aspect of pathology, it was the lowest concerning Her2 positive rate and the highest concerning triple negative rate in Uygur, even though ER and PR expression rates were no different in three groups.Concerning intervention type, the modified radical mastectomy was a major intervention type in three groups, but radical mastectomy proportion was highest in Uygur group.Conclusion: The incidence and the stage of breast cancer in Uygur women were younger and more advanced than that in other two groups.Maybe the prognosis in Uygur ethic group was worse than that in Han and Hui ethic groups and it showed that both of pregnancy and birth were not a risk factor in three groups.