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Objective: To investigate the effect of neoadjuvant chemotherapy(NAC) on biomarkers expression of breast cancer.Methods: The concordance rates of estrogen receptors (ER), progesterone receptors (PR), human epidermal growth factor (Her-2), p53, and Ki67 expressions by immunohistochemistry (IHC) between the preoperative core biopsy (CB) and excised tissue biopsies (EB) were studied in 277 NAC cases and 152 cases who did not receive NAC as control group.Results: In NAC group, the positive rates of HER2, ER, PR, Ki67,P53 by CB and EB were 6.9% & 5.8%, 66.4% & 63.9%, 57.1% & 47.3%, 68.9% & 44.7%, 57.0% & 50.0%,respectively; while in control group, the corresponding positive rates were 2.6% & 5.9%, 66.4% & 61.8%,50.7% & 49.3%, 66.0% & 70.4%, 58.9% & 45.7%, respectively.The differences of PR(P=0.001) and Ki67(P<0.001) between CB and EB in NAC group have statistical significance, so do P53(P=0.005) in control group.After neoadjuvant chemotherapy, PR and Ki67 status significantly altered from positive to negative (P<0.05).Conclusions: After neoadjuvant chemotherapy, its necessary to retest the biomarkers expression,especially, hormone receptor (HR) and Ki67, for optimizing the adjuvant systemic therapy and assessing the prognosis.