Jmjd3-mediated H3K27me3 dynamics orchestrate brown fat development and regulate white fat plasticity

来源 :The 2016 International Conference on Lipid Metabolism and Bi | 被引量 : 0次 | 上传用户：fulva

【摘要】

：

在棕色脂肪前体细胞中一系列棕色脂肪特异性基因的启动子区都有明显的组蛋白H3K27me3标记,在脂肪前体细胞向成熟脂肪细胞分化的过程中,这些H3K27me3标记在组蛋白去甲基化酶Jmjd3的催化作用下被去除,Jmjd3从而促进了成熟棕色脂肪细胞中Ucp1,Cidea等一系列棕色脂肪特异性基因的表达.Jmjd3在白色脂肪棕色化过程中也发挥了重要作用.在小鼠体内,Jmjd3转基因则可以明显抑制衰老引发的

【作者】

：

潘东宁

【出处】

：

The 2016 International Conference on Lipid Metabolism and Bi

【发表日期】

：

2016年11期

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Jmjd3-mediated H3K27me3 dynamics orchestrate brown fat development and regulate white fat plasticity

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