论文部分内容阅读
Proviral Integration Site in Moloney Murine Leukemia Virus Kinase 1(Pim-1)是一种高度保守的丝/苏氨酸激酶，在白血病、淋巴瘤以及前列腺癌等多种肿瘤组织中高度表达，有望成为肿瘤治疗的新靶点[1-5]。
基于喹啉片段的新型Pim-1激酶抑制剂的合成及生物活性研究
【摘 要】
：
Proviral Integration Site in Moloney Murine Leukemia Virus Kinase 1(Pim-1)是一种高度保守的丝/苏氨酸激酶，在白血病、淋巴瘤以及前列腺癌等多种肿瘤组织中高度表达，有望成为肿瘤治疗的新靶点[1-5]。
【机 构】
：
沈阳药科大学制药工程学院,教育部基于靶点的药物设计与研究重点实验室,辽宁 沈阳,110016
【出 处】
：
2015年全国药物化学学术会议暨第五届中英药物化学学术会议
【发表日期】
：
2015年3期
其他文献
目的：探讨外周中心静脉置管(PICC)(peripherally inserted central catheter)的临床应用特点及护理方法。方法：对我科2011年-2014年89例恶性肿瘤化疗患者进行PICC置管，观察置管的成功率，导管留置的时间，导管相关并发症及护理等。
会议
Survivin是凋亡抑制蛋白家族的一员，在细胞分裂和抑制细胞凋亡中起到关键作用，被认为是抗癌治疗的重要靶点。目前，只有少数的Survivin抑制剂被报道，并且大部分不是直接影响Survivin蛋白表达，而是通过与其他生物分子间的相互作用间接抑制Survivin的表达。
Cancer is a leading cause of death worldwide,accounting for 8.2 million deaths in 2012,lung cancer is the most common cause of cancer-related,and is responsible for 1.59 million deaths.
Design,synthesis and biological evaluation of novel imidazo[1,2-a]pyridine derivatives as potent ant
Antimitotic drugs play an important role in anti-tumor treatment,and various new scaffords of Tubulin inhibitors have been discovered.
MNK kinases phosphorylate the eukaryotic translation initiation factor eIF4E,which is a vital component of the translation machinery in the expression of important cancer-related proteins.
Hepatitis B virus(HBV)is one of the most serious and prevalent health problems.Approximately 350 million people in the world are chronically infected by HBV,lots of which develop liver cirrhosis and h
p21-activated kinases(PAKs)are a family of serine/threonine kinases that act downstream of Rho GTPases,Rac and Cdc42.
Synthesis of amide derivatives of scutellarin and their antioxidant and cardiovascular-protective ac
Natural products have made a significant impact in the development of cardiovascular-protective agents[1].Scutellarin is one of the main active ingredients in Erigeron breviscapus(Vant.)Hand-Mazz,whic
Carbonic anhydrases(CAs)are a family of enzymes comprised of 16 isoenzymes that can catalyze the hydration of carbon dioxide to a proton and bicarbonate anion and therefore play an important role in t
Design,synthesis and antifungal activity of Benzofuran derivatives as N-myristoyltransferase inhibit
Benzofuran derivatives(2)have been proved to be antifungal agents targeting fungal N-myristoyltransferase(NMT)with high selectivity between fungi and human[1].