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  5. The Study of In vitro and In vivo Transdermal Properties of 8-MOP Microemusion and Its Microe mulsio

The Study of In vitro and In vivo Transdermal Properties of 8-MOP Microemusion and Its Microe mulsio

来源 :2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会 | 被引量 : 0次 | 上传用户：yun603
【摘 要】
：
Objective To Study the in vitro and in vivo transdermal properties of 8-MOP microemusion and its microemulsion-based hydrogel.Method The 8-MOP microemusion and 8-MOP microemulsion-based hydrogel were
【作 者】
：
Ge Ou Dehua Liao Kai Zhang Daxiong Xiang 
【机 构】
：
Department of Pharmacy of the Second Xiangya Hospital,Hunan Changsha 4100112;Institute of clinical p
【出 处】
：
2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
【发表日期】
：
2014年8期
【关键词】
：
8-Methoxsalen microemulsion microemulsion-based hydrogel percutaneous administra 
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　　Objective To Study the in vitro and in vivo transdermal properties of 8-MOP microemusion and its microemulsion-based hydrogel.Method The 8-MOP microemusion and 8-MOP microemulsion-based hydrogel were determined using a modified Franz-type diffusion cell fitted with abdominal skin of excised anthony pig.Femal rats were used as experimental model and in vivo transdermal study of 8-MOP ME, MBH and commercially available solution were performed.After topical administrated preparation, blood samples were withdrawn from the fossa orbitalis of rats at predetermined time intervals, and after last blood sampled, cut off skin.8-MOP in rat plasma and skin was determined by HPLC.
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