【摘 要】
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Electrical resonance of excitable membranes has been proposed to underlie theta component of EEG, cognitive functions, epilepsy, and neuronal information proces
【机 构】
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DepartmentofBiomedicalEngineering,SchoolofMedicine,TsinghuaUniversity,Beijing,ChinaDepartmentofBiome
【出 处】
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The 9th Asian Biophysics Association Symposium (ABA2015)(第九届
论文部分内容阅读
Electrical resonance of excitable membranes has been proposed to underlie theta component of EEG, cognitive functions, epilepsy, and neuronal information processing.Voltage-gated ion channels (VGICs) provide the frequency preference of input currents across the membrane, known as M-resonance by M/KCNQ channels, or H-resonance by HCN channels.However, the detailed biophysical mechanisms and physiological roles of such electrical resonance remain elusive.In this study, we conducted an analytical decomposition of electrical resonance by linearization of subthreshold VGICs;also, we developed a multiple-sinusoid protocol to experimentally quantify electrical resonance.As proof of principle, these novel approaches were first verified upon phenomenal M-resonance and H-resonance well established in dorsal root ganglion neurons.We then reconstituted M-resonance and H-resonance with recombinant channels, all exhibiting resonant profiles well matched with linear-model predictions.By both experimental and/or modeling evidence, the biophysical origin of electrical resonance shared by both types of resonance is unveiled in this study;meanwhile the segregated roles of two types of resonance are also examined.Our data provide innovative insights into the design principles of ion channel-based electrical resonance that ensure specific physiological tasks.
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