TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can

来源 :The 9th Asian Biophysics Association Symposium (ABA2015)(第九届 | 被引量 : 0次 | 上传用户：zhaoshuang1989

【摘要】

：

Transactivation response element (TAR) DNA-binding protein 43 (TDP-43) is the principal component of ubiquitinated inclusions characteristic of most forms of am

【作者】

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Haina Qin Liangzhong Lim Yuanyuan Wei Jianxing Song

【机构】

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IntegrativeStructural&ComputationalBiologyDepartment,TheScrippsResearchInstitute,SanDiego,USADepartm

【出处】

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The 9th Asian Biophysics Association Symposium (ABA2015)(第九届

【发表日期】

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2015年5期

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Transactivation response element (TAR) DNA-binding protein 43 (TDP-43) is the principal component of ubiquitinated inclusions characteristic of most forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia-frontotemporal lobar degeneration with TDP-43-positive inclusions (FTLD-TDP), as well as an increasing spectrum of other neurodegenerative diseases.Previous structural and functional studies on TDP-43 have been mostly focused on its recognized domains.

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TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can

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