Multi-functionalized graphene oxide composite hydrogel for oral colon-specific drug delivery system

• 作 者: LinHou;GuixiangJiang;YatingWang;YuyangShi;QianhuaFeng;ZhenzhongZhang;
• 机 构: School of Pharmaceutical Sciences,Zhengzhou University,100 Kexue Avenue,Zhengzhou 450001,Henan,P.R.C
• 出 处: 中国微米纳米技术学会纳米科学技术分会第三届年会暨2014全国纳米生物与医学学术会议
• 发表日期: 2014年期

　　BaCkground: The oral aspect is considered to be most convenient for administration of drugs to patients.Currently,a novel oral colon-specific drug delivery system(OCDDS)has been exploring as one of the site-specific drug delivery system.There were a few strategies to achieve colonic specificity,such as bacterially triggered and pH-sensitivity OCDDS.Graphene oxide(GO),a two-dimensional(2D)carbon nanomaterial,possesses abundant hydrophilic oxygenated functional groups which enable GO to be functional through covalent or non-covalent approaches[1,2].