Inactivation of the tumor suppressor p53 and activation of the oncogene Ras are the two most pivotal events in tumor development.However,potential intersection between p53 and Ras activity during an E
Tumor cells commonly have increased glucose uptake and lactate accumulation.Lactate is produced from pyruvate by the lactate dehydrogenase A (LDH-A),which is frequently overexpressed in tumor cells an
Acrosome is a specialized organelle which covers the anterior part of sperm nuclear and plays essential role in sperm-egg fusion.Defect of acrosome biogenesis results in severe fertility disorder call
In the present study,monocytes were treated with 5-azacytidine (azacytidine),gossypol or hydrogen peroxide to induce cell death through oxidative stress.A shift from apoptotic to necrotic cell death o
丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPK)信号通路(Ras/Raf/MEK/ERK)是细胞内非常重要的信号转导通路,其异常激活或抑制可能引发如阿尔茨海默氏症、前列腺癌等疾病[1].Raf1蛋白激酶是MAPK信号通路中的一个重要的丝氨酸/苏氨酸特异性蛋白激酶.
The multidrug resistance 1 (MDR1) gene product P-glycoprotein is an ATP-dependent efflux pump associated with chemotherapy failure in breast cancer.In the present study,we show that paclitaxel induces