【摘 要】
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DEHP, Di-(2-ethylhexyl) phthalate, the most common phthalate plasticizer used in the production ofpolyvinyl chloride (PVC).Several in vivo studies have show
【机 构】
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Department of Bioscience Technology, Chung Yuan Christian University, Zhongli district, Taoyuan city
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DEHP, Di-(2-ethylhexyl) phthalate, the most common phthalate plasticizer used in the production ofpolyvinyl chloride (PVC).Several in vivo studies have shown that DEHP absorbed in the body is metabolized to produce MEHP, mono-ethylhexyl phthalate and other metabolite.The metabolite can be absorbed through the villi and travel in the circulation system then causes series damages in endocrine and reproductive system.In addition, investigations also demonstrated an association with elevated induction of rat hepatic cancer, testicular cancer, and developmental toxicity in reproductive system under MEHP exposure.However, the mechanism regarding to carcinogenicity induced by DEHP or its metabolite MEHP remains unclear up to date.
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