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Serotonin 2A receptor (5-HTR 2A) gene was implicated to be associated with major depressive disorder (MDD) susceptibility due to its role of key neurotransmitter in many physiologic processes.A great number of related studies reported in different populations have emerged.The results of these studies,however,have been inconsistent and thereby definite conclusions are difficult to establish.With the cumulative data in recent years,it was necessary to carry out a comprehensive analysis of previous findings.Therefore,we conducted the meta-analysis which combined all related studies using multiple research methods published up to January 2012 to give a new picture of the role of the 5-HTR 2A gene.In the meta-analysis of 19 case-control studies,including 2896 patients and 3709 controls,no significant association of MDD susceptibility with either T102C polymorphism or A-1438G polymorphism was found.When stratified by race for T102C polymorphism of the 5-HTR 2A,we also found no significant association.Compared with significant results reported previously,the current study did not support the association of the 5-HTR 2A gene with susceptibility to MDD.