Association of AFF1 rs340630 and AFF3 rs10865035 Polymorphisms with Systemic Lupus Erythematosus in

• 作 者: HanCen[1]Dong-QingYe[1]Rui-XueLeng[1]WeiWang[1]MoZhou[1]Chen-ChenFeng[1]Gui-MeiChen[1]RuiLi[1]Hai-FengPan[1]Xiang-PeiLi[2]
• 机 构: Department of Epidemiology and Biostatistics,School of Public Health,Anhui Medical University,81 Mei
• 出 处: 江西省科协第二届学术年会暨华东地区第十一次流行病学学术交流会议
• 发表日期: 2012年期

　　[Objective] The aim of this study was to evaluate whether two single-nucleotide polymorphisms (SNPs),AFF1 rs340630 and AFF3 rs10865035,show significant evidence for association with SLE in a Chinese population.[Methods] A total of 868 Chinese patients with SLE and 975 geographically-and ethnically-matched healthy control subjects were enrolled in the current study.The genotypes of these two SNPs were determined by Sequenom MassArray technology.[Results] Significant evidence for association of AFF3 rs10865035 with SLE was detected (for A versus G,p =4.81 × 10-4,odds ratio (OR) 1.26,95% confidence interval (95% CI) 1.11-1.44).However,no association between AFF1 rs340630 and SLE was found in the Chinese population (for A versus G,p =0.79,OR 0.98,95% CI 0.86-1.12).No significant evidence for association of AFF3 rs10865035 polymorphism with any clinical features was detected.[Conclusion] By targeting a variant with convincing evidence for association with RA,significant association of AFF3 rs10865035 with SLE was detected in the Chinese population,indicating AFF3 might be a common autoimmunity gene.Further case-control studies based on larger sample sizes in diverse ethnic populations are required to clarify the role of AFF1 rs340630 in SLE.