dFoxO promotes Wingless signaling in Drosophila

• 作 者: Shiping Zhang Xiaowei Guo Yujun Chen Changyan Chen Yang Yang Wenzhe Li Lei Xue
• 机 构: ShanghaiKeyLaboratoryofSignalingandDiseasesResearch,SchoolofLifeScienceandTechnology,TongjiUniversit
• 出 处: 2015亚太发育生物学国际研讨会
• 发表日期: 2015年9期
• 关键词: dFoxO Wg signaling Cell death Drosophila

　　The Wnt/β-catenin signaling is an evolutionarily conserved pathway that regulates a wide range of physiological functions, including embryogenesis, organ maintenance, cell proliferation and cell fate decision.Dysregulation of Wnt/β-catenin signaling has been implicated in various cancers, but its role in cell death has yet been fully elucidated.Here we show that activation of Wg signaling induces cell death in Drosophila eyes and wings, which depends on dFoxO, a transcription factor known to be involved in cell death.In addition, dFoxO is required for ectopic and endogenous Wg signaling to regulate wing patterning.Moreover, dFoxO is necessary for activated Wg signaling-induced target gene expression.Furthermore, Arm is reciprocally required for dFoxO-induced cell death.Finally, dFoxO physically interacts with Arm both in vitro and in vivo.Thus, we have characterized a previously unknown role of dFoxO in promoting Wg signaling, and that a dFoxO-Arm complex is likely involved in their mutual functions, e.g.cell death.