【摘 要】
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ObjectivePatient reported outcomes are important for clinical practice and research and should reflect what patients perceive as important.The objective of this study was to develop and preliminarily
【机 构】
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Division of Cancer Surgery and Transplantation Oslo University Hospital Norway
【出 处】
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2013百奥泰波兰重大疾病临床峰会
论文部分内容阅读
ObjectivePatient reported outcomes are important for clinical practice and research and should reflect what patients perceive as important.The objective of this study was to develop and preliminarily validate a brief, patient derived, disease-specific toot, thePAncreaticCAncer Disease Impact (PACADI) score.Methods The development was performed in two phases.Forty-one patients with conftrmed pancreatic cancer (PC) selected dimensions of health, related to the impact of the disease.A weighting of the eight most frequently reported dimensions was performed in a second sample of 80 PC patients, who also rated the impact on eight numeric rating scales.The relative weights and the scores from the NRS were used to compute the PACADI score (range 0 to 10).ESAS and EQ-5D were also completed.Results Dimensions reported by more than 20 % of the patients were included in the PACADI score The PACADI score in the 80 PC patients was moderately to strongly correlated to ESAS sense of well-being (r=0.69) and EQ-5D (r=-0.52), and discriminated significantly between patients with and without PC.Conclusion The PACADI score is a new eight-item, patient-derived, disease specific measure.Preliminary validation regarding construct validity and discrimination encourage further validation in independent patient samples.
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