IL-29联合人脐带间充质干细胞对食管癌细胞增殖和迁移的影响

来源 :首届全国组织修复与再生医学大会暨国际组织修复与再生医学学术研讨会 | 被引量 : 0次 | 上传用户：guoyh

【摘要】

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【作者】

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刘莎莎赵璇张震岳冬丽黄岚张毅

【机构】

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郑州大学第一附属医院生物细胞治疗中心,河南郑州450052;郑州大学生命科学学院,河南郑州450001

【出处】

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首届全国组织修复与再生医学大会暨国际组织修复与再生医学学术研讨会

【发表日期】

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2015年9期

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目的:人脐带间充质干细胞(human umbilical cord-derived mesenchymal stem cells,hUC-MSCs)对肿瘤有趋化性,而且免疫原性低、增殖力强、取材方便、来源广泛,具有广阔的应用前景.IL-29又名IFN-?1,具有抗病毒、抗肿瘤和免疫调节效应.本研究利用hUC-MSCs作为靶向运载工具,构建IL-29过表达慢病毒载体(pBpLV-IL29),探究过表达IL-29的hUC-MSCs向食管癌细胞趋化的能力及对其增殖的影响.方法:取正常足月剖宫产新生儿脐带,通过原代组织块贴壁法分离hUC-MSCs.

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IL-29联合人脐带间充质干细胞对食管癌细胞增殖和迁移的影响

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