Quantitative Site Specific Tyrosine Phosphorylation Analysis by Mass Spectrometry

• 作 者: JianzhuoLi;LianghaiHu;
• 机 构: School of Life Sciences,Jilin University,Changchun 130012,China
• 出 处: 中国化学会第30届学术年会
• 发表日期: 2016年期

　　Most kinases are initialized through the phosphorylation of activation loop and then activate the downstream signaling pathway subsequently.The activation of JAK2 kinase,a non receptor tyrosine kinase,which plays the important role in many growth factors and cytokines signaling pathway,will require the phosphorylation of tyrosine 1007 and 1008 sites.