A pharmacokinetic and metabolomic approach to the markers and underlying mechanism for the hypolipid

来源 :2015年第一届药代动力学朝阳论坛 | 被引量 : 0次 | 上传用户:jiangwei521521
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Berberine is characterized by its poorly gastrointestinal absorption and rather low bioavailability.Despite of the definite hypolipidemic effect following oral administration, the proposed mechanism can not well interpret the apparent contradiction between PK and PD.Our primary study of pharmacokinetics suggested that, in vivo berberine was too low to exert the therapeutic effect demonstrated in previous in vitro study, where berberine was trapped in gut content after the model hamsters were orally given with berberine.Meanwhile, although the exposure level of in-ragastric-administered berberine was much lower than that of intraperitoneal-administered berberine, it even had stronger lipid-lowing effect.Moreover, metabolomic study revealed that oral administration of berberine elevated the generation of bile acids, which failed to depress CYP7A1 by activating FXR signal pathway.
其他文献
PURPOSE: To evaluate the effect of scleral buckles on intraocular pressure (IOP) change in eyes with intravitreal gas during atmospheric decompression and thereby determine the feasibility of air trav
会议
目的:本研究通过观察糖尿病性视网膜病变的手术前后视力及并发症,探讨25G微创全玻璃体手术治疗增生性糖尿病性视网膜病变(PDR)的治疗效果.方法:回顾性分析了2013年5月至2015年1月在郑州市第二人民医院行初次PDR玻璃体手术的连续病例69例(86只眼).其中PDR Ⅳ期5例(5只眼),Ⅴ期17例(26只眼),Ⅵ期45例(55只眼),合并新生血管型青光眼5例(5只眼).方法:所有病例均行25G+
Purpose:To investigate the therapeutic effects and possible mechanisms of Alpha-Melanocyte Stimulating Hormone (α-MSH) on the rat dry eye model induced by scopolamine.Methods: The eye drop containing
目的:对经手术治疗的原发性肌锥内肿瘤进行回顾性研究,总结影像学特点,分析手术难点.方法:收集2010年1月至2014年12月天津市第一中心医院经手术治疗的原发性眼眶肌锥内肿瘤161例,其中男98例,女63例,年龄5-68岁,均单眼发病,左眶83例,右眶78例.海绵状血管瘤65例,静脉性畸形(静脉性血管瘤)33例,淋巴瘤38例,神经鞘瘤16例,纤维瘤4例,横纹肌肉瘤5例.主诉眼球突出122例,视力下
会议
Systemic lupus erythematosus (SLE) is a chronic heterogeneous autoimmune disease with protean manifestations.Although therapeutic advances over the last few decades have led to significant improvement
会议
The presence of autoantibodies is an important serological feature in autoimmune diseases.Autoantibodies are immunological manifestations of B cell immunity;they may be the actual pathogenic agents of
会议
The etiology of complex autoimmune and inflammatory diseases is multifactorial, and involves genetic, epigenetic, and environmental factors.Epigenetic changes, and particularly DNA methylation aberran
会议
Most drugs and other xenobiotics require metabolic activation in order to cause toxicity to cells.The extent to which metabolism in a given tissue or cell type contributes to xenobiotic toxicity in vi
会议
Estimation of the blood-brain barrier (BBB) permeability has long been a topic of major interest for the design of drugs with an intended pharmacological action in the central nervous system(CNS).Pres
会议
Drug metabolizing enzymes (DMEs) and transporters are important molecular determinants that affect ADME processes of xenobiotics such as drugs.For compounds that are involved with multiple mechanisms,
会议