Genomic Variability of HIV-1 and Resistance to Antiretroviral Drugs

来源 :2006中国天津世界艾滋病日科技会议 | 被引量 : 0次 | 上传用户:lujunjun_1204
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  Human Immunodeficiency virus (HIV) is composed of two viral types:HIV-1 and HIV-2.HIV-1 is pandemic.Sequence analysis of HIV-1 has allowed to classify this virus into three groups:M (major),O (outlier) and N (neither M nor O,new); O and N are observed in Central Africa,particularly in Cameroon.Viruses belonging to group M are observed in all parts of the world.Group M is sub-divided in subtypes and CRFs (circulating recombinant forms); subtypes are A,B,C,D,F,G,H,J and K; 34 CRFs have been described:among them,CRF01_AE is a recombinant between subtype A and an ancestral E subtype; CRF02_AG is a recombinant between subtypes A and G.The geographic repartition of these subtypes and CRFs is different from one continent to the other.Subtype B is predominant in western Europe,north America and Australia; CRF02_AG is predominant in west Africa; subtype C is frequently observed in India and CRF0 1_AE in south east Asia,particularly in Vietnam and Cambodia.
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