论文部分内容阅读
The HIV-1 reverse transcriptase (RT) has been a successful target for chemotherapeutic intervention.However,new drugs are urgently needed for systemic or for topical use as a microbicide due to the eventual emergence of drug-resistant strains of HIV-1 to currently available agents.The HIV-1 RT is an asymmetric dimer comprising a p66 and a p51 subunit,where the smaller subunit is the N-terminal cleavage product of p66.Studies by our group and others have demonstrated that the abrogation,destablisation or enlancement of RT dimerization impairs RT function.