【摘 要】
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1.The multidrug resistance phenomenon (MDR) impairs drug efficiency,leading to chemotherapeutic failure and hence causing a strong impact on disease outcome
【机 构】
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Institute of Biophysics Universidade Federal do Rio de Janeiro Brazil
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
1.The multidrug resistance phenomenon (MDR) impairs drug efficiency,leading to chemotherapeutic failure and hence causing a strong impact on disease outcome and patient survival.MDR can be mediated by several mechanisms,including the overexpression of effiux pumps belonging to the superfamily of the ATP-binding cassette proteins.Multidrug resistance associated protein (MRP1/ABCC1) is one of the transporters thought to beresponsible for the resistance of tumor cells to several chemically and functionally unrelated drugs.It has been suggested that MRP 1 can transport the drug alone or the drug conjugated to (GSH) or glucuronide or co-transported with these last two.
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