【摘 要】
：
In the adult mammals, axotomy of mature neurons in the central nervous system (CNS) triggers massive cell death and failure to spontaneous axon regeneration.The relationship between axotomy-induced ne
【机 构】
：
Key Laboratory of Brain Functional Genomics (Ministry of Education), Institute of Cognitive Neurosci
【出 处】
：
中国神经科学学会第九届全国学术会议暨第五届会员代表大会
论文部分内容阅读
In the adult mammals, axotomy of mature neurons in the central nervous system (CNS) triggers massive cell death and failure to spontaneous axon regeneration.The relationship between axotomy-induced neuronal death and axon regeneration has not yet well-understood, although promoting intrinsic capability of axon regeneration of CNS neurons is often accompanied by moderately improved neuronal survival.Here we generated a mouse line with conditional knock-out of apoptotic protease activating factor 1 (Apfa1).Apaf1 was deleted in retina ganglion cells (RGCs) by intravitreal injection of AAV-Cre virus, followed by optic nerve crush.Our data show that although Apaf1 is deleted, RGCs have significantly a high survival rate, but their axon regeneration ability is not restored.Therefore, axon regeneration is not the consequence of rescuing neuronal death.
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