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  5. Effect of molecular adjuvant inclusion in pH-sensitive polymer-modified liposomes on their performan

Effect of molecular adjuvant inclusion in pH-sensitive polymer-modified liposomes on their performan

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户：ADCADC111111
【摘 要】
：
Cancer immunotherapy requires effective antigen carriers to deliver antigen into the cytosol of dendritic cells (DCs),which induces antigen-specific cellular immune responses.Our previous study showed
【作 者】
：
Yuta Yoshizaki Eiji Yuba Naoki Sakaguchi Kazunori Koiwai Atsushi Harada Kenji Kono 
【机 构】
：
Department of Applied Chemistry,Graduate School of Engineering,Osaka Prefecture University,1-1 Gakue
【出 处】
：
The Third Symposium on Innovative Polymers for Controlled De
【发表日期】
：
2014年6期
【关键词】
：
cancer immunotherapy pH-sensitive liposome dendritic cell molecular adjuvant 
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　　Cancer immunotherapy requires effective antigen carriers to deliver antigen into the cytosol of dendritic cells (DCs),which induces antigen-specific cellular immune responses.Our previous study showed that pH-sensitive polymer modified-liposomes are effective antigen carriers to induce cellular immune responses [1].For practical antigen carrier,it is important not only to deliver antigen,but also to activate DCs (adjuvant effect).Activated DCs lead efficient antigen presentation and induce strong cellular immune responses.
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