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  5. Novel reversibly crosslinked chimaeric polypeptide polymersomes for active loading and intracellular

Novel reversibly crosslinked chimaeric polypeptide polymersomes for active loading and intracellular

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户：tower2008
【摘 要】
：
The disulfide-crosslinking approach has shown to elegantly resolve the extracellular stability and intracellular drug release dilemma of nanomedicines [1,2].In this study,novel reversibly crosslinked
【作 者】
：
Jintian Wu Xiaolei Gu Chao Deng Fenghua Meng Jian Zhang Ru Cheng Zhiyuan Zhong 
【机 构】
：
Biomedical Polymers Laboratory,and Jiangsu Key Laboratory of Advanced Functional Polymer Design and
【出 处】
：
The Third Symposium on Innovative Polymers for Controlled De
【发表日期】
：
2014年6期
【关键词】
：
polypeptide chimaeric polymersome reduction-sensitive intracellular release 
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　　The disulfide-crosslinking approach has shown to elegantly resolve the extracellular stability and intracellular drug release dilemma of nanomedicines [1,2].In this study,novel reversibly crosslinked chimaeric polymersomes were developed from lipoic acid (LA) decorated poly(ethylene glycol)-poly(L-lysine)-poly(L-aspartic acid) (PEG-P(LL-LA)-PAsp) triblock copolymers for efficient loading and triggered intracellular release of doxorubicin hydrochloride (DOX·HC1).LA is a natural antioxidant produced by human body.
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