• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. 缺氧诱导因子-1α的表达与肾癌细胞增殖和凋亡研究

缺氧诱导因子-1α的表达与肾癌细胞增殖和凋亡研究

来源 :GTAUF2014 & APSMHA2014第六届长城泌尿男科转化医学论坛暨第七届亚太男性健康与抗衰老研究学会年会 | 被引量 : 0次 | 上传用户：pkutraining
【摘 要】
：
目的:探讨缺氧诱导因子-1α(HIF-1α)在肾癌组织中表达及其与Bcl-2和PCNA的关系,了解肿瘤增殖与凋亡的特点.方法:采用免疫组织化学方法检测61例肾癌石蜡标本切片HIF-1α、Bc1-2和PCNA的表达.结果:HIF-1α在肾癌组织中阳性率为57.4％(35/61),其表达与不同临床分期、病理分级有关(P＜0.05),与组织学分类无关(P＞0.05).Bcl-2在肾癌组织中阳性率为42.
【作 者】
：
孟平 王禾 张更 于磊 
【机 构】
：
第四军医大学西京医院泌尿外科,西安710032,中国
【出 处】
：
GTAUF2014 & APSMHA2014第六届长城泌尿男科转化医学论坛暨第七届亚太男性健康与抗衰老研究学会年会
【发表日期】
：
2014年11期
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
目的:探讨缺氧诱导因子-1α(HIF-1α)在肾癌组织中表达及其与Bcl-2和PCNA的关系,了解肿瘤增殖与凋亡的特点.方法:采用免疫组织化学方法检测61例肾癌石蜡标本切片HIF-1α、Bc1-2和PCNA的表达.结果:HIF-1α在肾癌组织中阳性率为57.4％(35/61),其表达与不同临床分期、病理分级有关(P＜0.05),与组织学分类无关(P＞0.05).Bcl-2在肾癌组织中阳性率为42.6％(26/61),其表达与组织学分类、临床分期、病理分级均无关(p＞0.05).HIF-1α表达与肾癌细胞增殖程度呈正相关性(r=0.489,P=0.000);与Bcl-2蛋白表达无相关性(r=-0.196,P=0.127).
其他文献
Prevalence and factors associated with baseline chronic kidney disease in China: a 1O-year study of
Background/Purpose: There is relatively little literature on prevalence of chronic kidney disease (CKD) prior to surgery in patients with upper urinary tract urothelial carcinoma (UTUC).We evaluated t
会议
UTUC patientschronic kidney disease (CKD)prevalence and factors
Prognostic and predictive value of epigenetic biomarkers in upper tract urothelial carcinoma: a larg
Purpose: Epigenetic biomarkers and prognostic clinical factors in upper tract urothelial carcinoma (UTUC) are inconclusive.We conducted this study to identify gene promoter methylation status and pred
会议
Epigenetic biomarkersupper tract urothelial carcinoma (UTUC)gene promoter meth
Advances of surgical treatment in male infertility
Approximately 15％ of couples cannot conceive a child after 1 year of regular, unprotected intercourse.Male factor infertility is contributory in another 30％ to 40％.Most causes of male infertility are
会议
Male infertilitysurgical treatmentcongenial bilateral absence of the vas defer
An easy model for prediction of human renal clear cell carcinoma-curve fitting for 3 kidney tumors o
Objective: To accurately describe the growth of human renal clear cell carcinoma.In our earlier research, the growth model of renal tumors is linear and is not accurate.A better growth model is needed
会议
Human renal clear cell carcinomakidney tumorsgrowth model
The study of cell proliferation and apoptosis and autophagyin renal cell carcinoma cells influence b
Objective: The research is to study the cell proliferation and apoptosis and autophagyin renal cell carcinoma cells influence by the PI3K/AKT/mTor inhibitor NVPBEZ235.Looking for a new treatment strat
会议
Renal cell carcinomaNVP-BEZ235autophagyapoptosis
The first clinical research in the world of combined kidney transplantation and splenic fossa auxili
Objective: To study the clinical effect of combined kidney transplantation and splenic fossa auxiliary heterotopic liver transplantation to treat highly sensitized recipients.Methods: Combined kidney
会议
Kidney transplantationsplenic fossa auxiliary heterotopic liver transplantation
Association of mitochondrial DNA copy number in peripheral blood leukocytes with risk and prognosis
Objective: To investigate the relationship between mitochondrial DNA (mtDNA) copy number in peripheral blood leukocytes (PBLs) and the risk and the prognosis of prostate cancer (PCa).Methods: In a cas
会议
Prostate cancer (Pca)mitochondrial DNA (mtDNA)cancer riskprognosis
MicroRNA124 regulate cell growth of prostate cancer cells by targeting iASPP
Protein phosphatase 1, regulatory subunit 13 like PPP1R13L, also coined iASPP, was found high expression in prostate cancer tissues and cell lines.In previous research, in vitro and in vivo RNAi media
会议
Mir124iAsPPprostate cancercell growth
Laparoscopic ureteral reimplantation underneath broad ligament tunnel for female vesicoureteral sten
Purpose: In order to anatomically reconstruct the ureteral stenosis, we present a novel technique for laparoscopic ureteral reimplantation.Patients and methods: Three young females, who were diagnosed
会议
Ureteral stenosislaparoscopic ureteral reimplantationtunnel
Functional oromoter-94 ins/del ATTG polymorphism in NFKB1 gene is associated with bladder cancer ris
Background: A functional-94 insertion/deletion polymorphism (rs28362491) in the promoter of the NFKB1 gene was reported to influence NFKB1 expression and confer susceptibility to different types of ca
会议
94 ins/del ATTG polymorphismNFKB 1 genebladder cancer riskTaqMan assay